2021 USCAP Maude Abbott Lecture – Neuroendocrine Carcinomas o ke poʻo a me ka ʻāʻī:
I hala, i kēia manawa a me ka wā e hiki mai ana

BRUCE M. WENIG, MD

Lunahoomalu ame Luna Nui
Oihana Pathology
Hale Waihona Moffitt Cancer
Kumu o ka Oncological Science
Ke Kulanui o South Florida
ʻO Tampa, Florida

Ka manawa holo: 1 hola 26 minuke

PALAHANA PALAPALA

ʻO nā neoplasms Neuroendocrine (NEN) e kū mai ma kahi kokoke i kēlā me kēia ʻāpana. ʻO ka ulu ʻana o ka embryologic o NEN ke kumu o ka hoʻopaʻapaʻa inā aia a ʻaʻole kahi kumu neural crest maʻamau. Ma lalo o ka manaʻo o kahi kumu neural crest maʻamau, ʻo ke ʻano o kahi ala biochemical maʻamau i nā cell neuroendocrine e komo ana i ka uptake a me ka decarboxylation o nā amine precursors i hoʻopaʻa ʻia e ʻae ʻia i kēia mau cell e ʻike ʻia i ka histochemically a hopena i ka hoʻohana ʻana i ka acronym APUD (Amine Precursor. Uptake a me Decarboxylation) e wehewehe i nā pūnaewele ma kēia ʻōnaehana. Ua hōʻole ʻia nā haʻawina ma hope mai i kahi kumu neural crest maʻamau a ua hoʻopaʻa ʻia ka Dispersed Neuroendocrine Cell System no NEN. ʻO ka hoʻokaʻawale ʻana o NEN ua loaʻa i kahi loli kahi i manaʻo ʻia ai nā papahana o kēia manawa me ka nānā ʻole i ke kahua o ke kumu i hoʻohana ʻia ai ka nomenclature i hoʻokumu ʻia no ka ʻōpū a me ka pancreatic NEN. Ma waho aʻe o ka ʻōpū o ka ʻōpū, ka pancreas a me ka māmā, ʻo ka ʻāpana poʻo a me ka ʻāʻī kekahi o nā wahi maʻamau o ka NEN a ma loko o kēia ʻāpana neuroendocrine carcinoma ka ʻano maʻamau o ka pūnaewele NEN kikoʻī. E kālele ana kēia kamaʻilio ʻana i nā carcinomas neuroendocrine o ke poʻo a me ka ʻāʻī e nānā ana i kā lākou mau clinicopathologic hiʻohiʻona a kūkākūkā i kā lākou hoʻokomo ʻana i loko o kahi papa hana hoʻohālikelike i manaʻo ʻia no NEN kikoʻī ʻē aʻe.

NĀ AINA KULA

1. Kūkākūkā i ka ulu ʻana o ka embryologic o nā neoplasms neuroendocrine
2. E wehewehe i nā pae hoʻohālikelike no nā neoplasms neuroendocrine poʻo a me ka ʻāʻī e ʻokoʻa ana i kēia mau pae hoʻohālike me nā pae NEN kikoʻī ʻē aʻe.
3. E noʻonoʻo inā pili ka papa hana hoʻohālikelike maʻamau no NEN i ke poʻo a me ka ʻāʻī NEN